منابع مشابه
Overcoming tumour hypoxia
Cancer occurs as a result of genetic changes and the uncontrolled proliferation of abnormal cells that escape normal homeostatic control mechanisms. As tumour growth outstrips blood supply, cells become hypoxic and the decreased oxygen levels stimulate responses to maximise the chance of cell survival. These biological responses to hypoxia promote aggressive features in tumour cells. Also, hypo...
متن کاملPET imaging of tumour hypoxia
Tumour hypoxia represents a significant challenge to the curability of human tumours leading to treatment resistance and enhanced tumour progression. Tumour hypoxia can be detected by non-invasive and invasive techniques but the inter-relationships between these remains largely undefined. [18F]Fluoromisonidazole-3-fluoro-1-(2'-nitro-1'-imidazolyl)-2-propanol ([18F]MISO) and Cu-diacetyl-bis(N4-m...
متن کاملTumour radiobiology beyond fractionation
Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...
متن کاملReducing Tumour Hypoxia via Oral Administration of Oxygen Nanobubbles
Hypoxia has been shown to be a key factor inhibiting the successful treatment of solid tumours. Existing strategies for reducing hypoxia, however, have shown limited efficacy and/or adverse side effects. The aim of this study was to investigate the potential for reducing tumour hypoxia using an orally delivered suspension of surfactant-stabilised oxygen nanobubbles. Experiments were carried out...
متن کاملThe anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
Tumour hypoxia renders cancer cells resistant to cancer therapy, resulting in markedly worse clinical outcomes. To find clinical candidate compounds that reduce hypoxia in tumours, we conduct a high-throughput screen for oxygen consumption rate (OCR) reduction and identify a number of drugs with this property. For this study we focus on the anti-malarial, atovaquone. Atovaquone rapidly decrease...
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ژورنال
عنوان ژورنال: Clinical Oncology
سال: 2019
ISSN: 0936-6555
DOI: 10.1016/j.clon.2019.06.008